Targeted Cancer Therapeutics
نویسندگان
چکیده
منابع مشابه
Predicting Targeted Cancer Therapeutics
Motivation: Cancer is a complex and evolving disease, making it difficult to discover effective treatments. Traditional drug discovery relies on high-throughput screening on reductionist models in order to enable the testing of 105 or 106 compounds. These assays lack the complexity of the human disease. Functional assays overcome this limitation by testing drugs on human tumors, however they ca...
متن کاملTargeted cancer therapeutics.
Targeted therapies can be defined as drugs developed against a specific target based on its important biological function in cancer. In contrast, nontargeted therapies are drugs identified by phenotypic screening of natural products or chemical libraries against established cancer cell lines or preclinical animal models without a priori knowledge of the target. Targeted therapies are designed t...
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The majority of growth factor receptors are composed of extracellular, transmembrane, and cytoplasmic tyrosine kinase (TK) domains. Receptor tyrosine kinase (RTK) activation regulates many key processes including cell growth and survival. However, dysregulation of RTK has been found in a wide range of cancers, and it has been shown to correlate with the development and progression of numerous c...
متن کاملNanotechnology for Targeted Delivery in Cancer Therapeutics
Recent advances in nanotechnology has shown tremendous promise to revolutionize cancer therapeutics by generating new therapies that might allow more efficient targeted delivery of anticancer agents to kill cancerous cells or tumors and imaging agents for diagnosis of various cancers. But, before application of nanoparticle-based targeted delivery systems, significant challenges related to clin...
متن کاملTargeted Therapeutics
Deciphering the molecular underpinnings of a disease is often only the first step toward developing an effective treatment. The path from target identification to a successful therapeutic can be filled with numerous hurdles that call for creative strategies. This Select highlights recent advances in using gene therapy and engineered cells to treat cancers and chronic heart disease. Their succes...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2009
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-08-3836